Symbol
Name
ID

Vapb
vesicle-associated membrane protein, associated protein B and C
MGI:1928744

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Dysphagia

Spasticity

Fatigable weakness of bulbar muscles

Fatigable weakness of swallowing muscles

Fatigable weakness of respiratory muscles

Motor neuron atrophy

Amyotrophic lateral sclerosis

Abnormal pyramidal tract morphology

Neurodegeneration

Neuronal loss in central nervous system

Fasciculations

Tremor

Postural tremor

Paralysis

Abnormal pyramidal sign

Babinski sign

Dysarthria

Language impairment

Depression

Emotional lability

Anxiety

Atypical behavior

Agitation

Cognitive impairment

Frontotemporal dementia

Sleep abnormality

Hyperreflexia

Jaw hyperreflexia

Areflexia

Hyporeflexia

Loss of ambulation

Shuffling gait

Waddling gait

Bulbar signs

Disease(s) Associated with VAPB

amyotrophic lateral sclerosis

amyotrophic lateral sclerosis type 8

autosomal dominant adult-onset proximal spinal muscular atrophy

Mouse Phenotypes		nervous system phenotype	abnormal synaptic bouton morphology	abnormal neuromuscular synapse morphology	neuronal cytoplasmic inclusions	axon degeneration
Availability	Mouse Genotype	nervous system phenotype	abnormal synaptic bouton morphology	abnormal neuromuscular synapse morphology	neuronal cytoplasmic inclusions	axon degeneration
	Vapb^tm1.1Tsud/Vapb^tm1.1Tsud
	Vapb^tm1.2Ics/Vapb^tm1.2Ics	*
	Vapb^tm1.1Tsud/Vapb⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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